Elizabeth Thompson, M.D., Ph.D, was born and raised in Galveston, Texas, and graduated from the College of William and Mary with a B.S. in biology. She then earned her M.D. and Ph.D. degrees from the University of Virginia where her thesis work focused on CD8 T cell responses to melanoma and differences in the tumor immune microenvironment based on tumor location. Dr. Thompson completed her pathology residency at Hopkins and served as chief resident from 2014-2015. Her clinical interests focus on pancreatic pathology, and her research efforts will center on the immune microenvironment of pancreatic tumors and on the development of strategies for immunotherapy in pancreatic cancer. Dr.Thompson joined the Division of Surgical Pathology in July 2016.
Selected Publications
- White MJ, …, Thompson ED. Continuing Undergraduate Pathology Medical Education in the Coronavirus Disease 2019 (COVID-19) Global Pandemic: The Johns Hopkins Virtual Surgical Pathology Clinical Elective. Arch Pathol Lab Med. 2021 Jul 1;145(7):814-20.
- Cloutier J, Thompson ED, Cimino-Mathews A, Rooper LM, Matoso A, Argani P. Metastatic breast cancer simulating well-differentiated neuroendocrine neoplasms of visceral organs. Hum Pathol 2018 Dec;82:76-86
- Huang B, ..., Hruban RH, Eshleman JR, Thompson ED, Klein AP, Goggins M, Wood LD, Roberts NJ. Molecular characterization of organoids derived from pancreatic intraductal papillary mucinous neoplasms. J Pathol 2020;252(3):252-62
- Rooper LM, Uddin N, Gagan J, Brosens LAA, Magliocca KR, Edgar MA, Thompson LDR, Agaimy A, Bishop JA. Recurrent Loss of SMARCA4 in Sinonasal Teratocarcinosarcoma. Am J Surg Pathol 2020 Oct;44(10):1331-9
- Fujikura K, Hosoda W, …, Roberts NJ, Thompson ED, … Wood LD. Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions. Gut 2021 May;70(5):928-39.
- Hong SM, Noë M, Hruban CA, Thompson ED, Wood LD, Hruban RH. A “clearer” view of pancreatic pathology: a review of tissue clearing and advanced microscopy techniques. Adv Anat Pathol 2019 Jan;26(1):31-9. (REVIEW)
- Fujikura K, Hutchings D, Braxton AM, Zhu Q, Laheru DA, Hruban RH, Thompson ED, Wood LD. Intraductal pancreatic cancer is less responsive than cancer in the stroma to neoadjuvant chemotherapy. Mod Pathol 2020 Oct;33(10):2026-34.
- Noë M, Hong SM, Wood LD, Thompson ED, Roberts NJ, Goggins MG, Klein AP, Eshleman JR, Kern SE, Hruban RH. Review: Pancreatic cancer pathology viewed in the light of evolution. Cancer Metastasis Rev. 2021 Sep;40(3):661-74
- Felsenstein M, Trujillo MA, …, Goggins MG, Hruban RH, Thompson ED, Heaphy CM, Roberts NJ, Wood LD. Generation and characterization of a cell line from an intraductal tubulopapillary neoplasm of the pancreas. Lab Invest 2020 Jul;100(7):1003-13
- Huang W, …, Wolfgang CL, Goggins MG, Thompson ED, Roberts NJ, Ewald AJ, Wood LD. Pattern of invasion in human pancreatic cancer organoids is associated with loss of SMAD4 and clinical outcome. Cancer Res 2020 July;80(13):2804-17.
- Cottrell TR, Thompson ED, …, Cimino-Mathews A, Taube JM. Pathologic Features of Response to Neoadjuvant Anti-PD-1 in Resected Non-Small Cell Lung Carcinoma: A Proposal for Quantitative Immune-Related Pathologic Response Criteria (irPRC). Ann Oncol. 2018 A
- Hong SM, Jung D, …, Oshima K, Thompson ED, …, Wirtz D, Hruban RH, Wood LD. 3-D visualization of cleared human pancreas cancer reveals that sustained epithelial-to-mesenchymal transition is not required for venous invasion. Mod Pathol 2020;33:639
- Stein JE, Lipson EJ, Cottrell TR, Forde PM, Anders RA, Cimino-Mathews A, Thompson ED, …, Jaffee EM, Pardoll DM, Topalian SL, Taube JM. Pan-Tumor Pathologic Scoring of Response to PD-(L)1 Blockade. Clin Cancer Res 2020 Feb;26(3):545-51
- Thompson ED, Roberts NJ, Wood LD, Eshleman JR, Goggins MG, Kern SE, Klein AP, Hruban RH. Review: The genetics of ductal adenocarcinoma of the pancreas in the year 2020: dramatic progress, but far to go. Mod Pathol 2020 Dec;33(12):2544-63