Rapid Autopsy


Publications

  • Grasso CS, Tang Y, Truffaux N, Berlow NE, Liu L, Debily MA, Quist MJ, Davis LE, Huang EC, Woo PJ, Ponnuswami A, Chen S, Johung TB, Sun W, Kogiso M, Du Y, Qi L, Huang Y, Hütt-Cabezas M, Warren KE, Le Dret L, Meltzer PS, Mao H, Quezado M, van Vuurden DG, Abraham J, Fouladi M, Svalina MN, Wang N, Hawkins C, Nazarian J, Alonso MM, Raabe EH, Hulleman E, Spellman PT, Li XN, Keller C, Pal R, Grill J, Monje M. Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nat Med. 2015 May 4.

  • Haffner M.C., et al. Diagnostic challenges of clonal heterogeneity in prostate cancer. J Clin Oncol. 2015;33(7): p. e38-40.

  • Taylor IC, Hütt-Cabezas M, Brandt WD, Kambhampati M, Nazarian J., Chang HT, Warren KE, Eberhart CG, Raabe EH. Disrupting NOTCH slows diffuse intrinsic pontine glioma growth, enhances radiation sensitivity, and shows combinatorial efficacy with bromodomain inhibition. J Neuropathol Exp Neurol. Vol. 74, No. 8 August 2015.

Past Publications

Breast Cancer

  • Shipitsin M., et al. Molecular definition of breast tumor heterogeneity. Cancer Cell. 2007;11(3):259-73. PMID: 17349583
  • Wu J.M., et al. Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases. Clin Cancer Res. 2008;14(7):1938-46.
    PMID: 18381931
  • Bloushtain-Qimron N., et al. Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A. 2008;105(37):14076-81.
    PMID: 18780791
  • Cao D., et al. Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9. Breast Cancer Res. 2008;10(5):R91. PMID: 18954444
  • Cimino A., et al. Epithelial cell adhesion molecule (EpCAM) is overexpressed in breast cancer metastases. Breast Cancer Res Treat. 2010;123(3):701-8. PMID: 20012351
  • Wu J.M., et al. Intratumoral heterogeneity of HER-2 gene amplification and protein overexpression in breast cancer. Hum Pathol. 2010;41(6):914-7.
    PMID: 20338615
  • Subhawong A.P., et al. Heterogeneity of Bcl-2 expression in metastatic breast carcinoma. Mod Pathol. 2010;23(8):1089-96. PMID: 20495533
  • Cimino-Mathews A., et al. Androgen receptor expression is usually maintained in initial surgically resected breast cancer metastases but is often lost in end-stage metastases found at autopsy. Hum Pathol. 2012;43(7):1003-11.
    PMID: 22154362

Pancreatic Cancer

  • Iacobuzio-Donahue C.A., et al. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol. 2009. 27(11): p. 1806-13.
  • Yachida S., et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature. 2010. 467(7319): p. 1114-7.

Pediatric Cancers

  • Alabran JL, Hooper JE, Smith SE, Spady KK, David LE, Peterson LS, Malempati s, Ryan CW, Acosta R, Spunt SL, Keller C. Overcoming autopsy barriers in pediatric cancer research. Pediatr Blood Cancer 2013 Feb;60:204-9.

Prostate Cancers

  • Aryee M.J., et al. DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases. Sci Transl Med. 2013;5(169): p. 169ra10.
  • Cimino-Mathews A., et al. GATA3 expression in breast carcinoma: utility in triple-negative, sarcomatoid, and metastatic carcinomas. Hum Pathol. 2013 Jul;44(7):1341-9. PMID: 23375642
  • Antonarakis E.S., et al. Resistance to androgen-pathway drugs in prostate cancer. N Engl J Med. 2014;371(23): p. 2234.

Sarcomas

  • Kikuchi K, Wettach GR, Ryan CW, Hung A, Hooper JE, Beadling C, Warrick A, Corless CL, Olson SB, Keller C, Mansoor A. MDM2 amplification and PIK3CA mutation in a case of sclerosing rhabdomyosarcoma. Sarcoma 2013;2013:520858. PMID: 23766666