Molecular Genetics Laboratory of Female Reproductive Cancer

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The long-term objectives of our research team are to:

  • understand the molecular etiology of female reproductive cancers
  • elucidate the mechanics of chemoresistance in ovarian cancer
  • translate basic research into potential clinical promise

We use ovarian carcinoma as a primary disease model because it is one of the most aggressive neoplastic diseases for women. Our research team aims to understand the molecular basis behind how normal cells are transformed, selected, and evolve to become invasive carcinoma. Genome-wide analyses at Hopkins have identified molecular genetic alterations in different types of ovarian cancers including NOTCH3, ARID1A, PIK3CA, PPP2R1A, among several others. We are currently focusing on revealing the tumor-promoting functions of NOTCH3 signaling and tumor-suppressor functions of the ARID1A pathway. In addition, we are characterizing metabolic reprograming during the development of platinum drug resistance. The ultimate goal is to translate our research findings into new preventive and therapeutic strategies. We are in collaboration with a team of dedicated clinicians and scientists across multiple disciplines to achieve this goal. Support our research »

» Click here for the Ovarian Cancer Specialized Program of Research Excellence (SPORE) Website

"What we observe is not nature itself, but nature exposed to our method of questioning."
-- Werner Heisenberg, Physics and Philosophy, 1958


Tian-Li Wang, PhD

Tian-Li Wang, PhD
Director

Professor; Director of the Molecular Genetics Laboratory of Female Reproductive Cancer
Departments of Pathology, Oncology, and Gynecology & Obstetrics
Faculty in Pathobiology Graduate Program
Johns Hopkins Medical Institutions

National Taiwan University, BS
Johns Hopkins University School of Medicine, PhD
University of Pennsylvania, School of Medicine, Post-doc fellow (Neuroscience)
Mentors: Drs. Peter Sterling and Noga Vardi

Howard Hughes Medical Institutions, Associate (Cancer Genetics)
Mentors: Drs. Bert Vogelstein and Kenneth Kinzler

Faculty Collaborator
Ie-Ming Shih, MD, PhD Ie-Ming Shih, MD, PhD
Co-Director, Breast & Ovarian Cancer Program
Sidney Kimmel Comprehensive Cancer Center
Director, Telinde GYN Pathology Research Program

Richard W. TeLinde Professor
Department of Gynecology & Obstetrics
Departments of Pathology and Oncology
Faculty in Pathobiology Graduate Program
Johns Hopkins University School of Medicine

Taipei Medical University, MD
University of Pennsylvania, PhD
Johns Hopkins University, Residency (Pathology)
Johns Hopkins University, Fellowships (Gynecologic Pathology and Cancer Genetics)

Faculty Collaborator
Thomas R Pisanic II, PhD Thomas R Pisanic II, PhD
Assistant Research Scientist
Institute for NaoBioTechology
Johns Hopkins University

Johns Hopkins University, BS
University of California, San Diego, PhD
Johns Hopkins University, Post-doc fellow (Bioengineering)

Research focus: Development of innovative molecular analysis techniques to achieve inexpensive epigenetic assessment strategies for early detection of human cancers


Support our Research

Support our Cancer Genetics Research for Female Reproductive Cancers at Johns Hopkins. Our research focused on elucidating the roles of genetic and epigenetic factors in BRCA1/2 mutated and sporadic ovarian cancers.

To reduce the burden and mortality of ovarian cancer, we focused on early detection using biomarkers identified by our team and have assembled a multi-disciplinary research team to achieve this goal.

Johns Hopkins University is a 501(c)3, non-profit organization. Any gift to our Institution is tax deductible and can be made payable to "The Johns Hopkins Department of Pathology" and mail to:

Molecular Genetics Laboratory
of Female Reproductive Cancer —TL Wang
c/o Robert Kahl
Department of Pathology
Johns Hopkins Medicine
600 N. Wolfe Street, Carnegie 424
Baltimore, MD 21287-6417

To donate by credit card online, please visit our secure online giving form. Under Designate My Gift to Support, choose "Other (Please Specify)" and under Please Describe, put "Molecular Genetics Laboratory of Female Reproductive Cancer".


Acknowledgements

We gratefully acknowledge funding support from the following sources who have made our work possible.

Private Foundations

  • Ovarian Cancer Research Fund Alliance (OCFRA)
  • The Honorable Tina Brozman Foundation - Tina's Wish
  • Colleen's Dream Foundation
  • Team Katie Oppo - Ovarian Cancer Research Fund
  • Endometriosis Foundation of America
  • Ephraim & Wilma Shaw Roseman Foundation
  • American Cancer Society
  • Gray Foundation - for BRCA research

Government funding

  • National Institutes of Health/National Cancer Institute
  • Department of Defense - Ovarian Cancer Research Program