Rapid Autopsy


Publications

General +
  • Hooper and Williamson (Eds.), Autopsy in the 21st Century. Best Practices and Future Directions. Springer International Publishing (2018), including the first two chapters on rapid autopsy (one by Hooper/Duregon and one by Fan/Iacobuzio) published in any book to date.

  • Ho WJ,Yarchoan M,Charmsaz S,Munday RM,Danilova L,Sztein MB,Fertig EJ,Jaffee EM. Multipanel mass cytometry reveals anti-PD-1 therapy-mediated B and T cell compartment remodeling in tumor-draining lymph nodes. JCI Insight. 2020 Jan 30;5(2):. doi: 10.1172/jci.insight.132286. PubMed PMID: 31855578; PMCID: PMC7098715.

  • Iacobuzio-Donahue CA,Michael C,Baez P,Kappagantula R,Hooper JE,Hollman TJ. Cancer biology as revealed by the research autopsy. Nat Rev Cancer. 2019 Dec;19(12):686-697. doi: 10.1038/s41568-019-0199-4. PubMed PMID: 31519982; PMCID: PMC7453489.

  • Duregon E,Schneider J,DeMarzo AM,Hooper JE. Rapid research autopsy is a stealthy but growing contributor to cancer research. Cancer. 2019 Sep 1;125(17):2915-2919. doi: 10.1002/cncr.32184. PubMed PMID: 31090935; PMCID: PMC6690796.

  • Forster KR,Hooper JE,Blakemore KJ,Baschat AA,Hoover-Fong J. Prenatal diagnosis of Desbuquois dysplasia Type 1: Utilization of high-density SNP array to map homozygosity and identify the gene. Am J Med Genet A. 2019 Dec;179(12):2490-2493. doi: 10.1002/ajmg.a.61372. PubMed PMID: 31587486


Breast Cancer +
  • Ding L,Su Y,Fassl A,Hinohara K,Qiu X,Harper NW,Huh SJ,Bloushtain-Qimron N,Jovanović B,Ekram M,Zi X,Hines WC,Aleĉković M,Gil Del Alcazar C,Caulfield RJ,Bonal DM,Nguyen QD,Merino VF,Choudhury S,Ethington G,Panos L,Grant M,Herlihy W,Au A,Rosson GD,Argani P,Richardson AL,Dillon D,Allred DC,Babski K,Kim EMH,McDonnell CH 3rd,Wagner J,Rowberry R,Bobolis K,Kleer CG,Hwang ES,Blum JL,Cristea S,Sicinski P,Fan R,Long HW,Sukumar S,Park SY,Garber JE,Bissell M,Yao J,Polyak K. Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ. Nat Commun. 2019 Sep 13;10(1):4182. doi: 10.1038/s41467-019-12125-5. PubMed PMID: 31519911; PMCID: PMC6744561.

  • Cimino-Mathews A., et al. Androgen receptor expression is usually maintained in initial surgically resected breast cancer metastases but is often lost in end-stage metastases found at autopsy. Hum Pathol. 2012;43(7):1003-11. PMID: 22154362.

  • Subhawong AP, Nassar H, Halushka MK, Illei PB, Vang R, Argani P. Heterogeneity of Bcl-2 expression in metastatic breast carcinoma. Mod Pathol. 2010 Aug;23(8):1089-96. doi: 10.1038/modpathol.2010.93. Epub 2010 May 21. PMID: 20495533; PMCID: PMC4863939.

  • Wu JM, Halushka MK, Argani P. Intratumoral heterogeneity of HER-2 gene amplification and protein overexpression in breast cancer. Hum Pathol. 2010 Jun;41(6):914-7. doi: 10.1016/j.humpath.2009.10.022. Epub 2010 Mar 24. PMID: 20338615; PMCID: PMC2958099.

  • Cimino A, Halushka M, Illei P, Wu X, Sukumar S, Argani P. Epithelial cell adhesion molecule (EpCAM) is overexpressed in breast cancer metastases. Breast Cancer Res Treat. 2010 Oct;123(3):701-8. doi: 10.1007/s10549-009-0671-z. Epub 2009 Dec 11. PMID: 20012351; PMCID: PMC3042397.

  • Cao D, Polyak K, Halushka MK, Nassar H, Kouprina N, Iacobuzio-Donahue C, Wu X, Sukumar S, Hicks J, De Marzo A, Argani P. Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9. Breast Cancer Res. 2008;10(5):R91. doi: 10.1186/bcr2189. Epub 2008 Oct 27. PMID: 18954444; PMCID: PMC2614499.

  • Bloushtain-Qimron N, Yao J, Snyder EL, Shipitsin M, Campbell LL, Mani SA, Hu M, Chen H, Ustyansky V, Antosiewicz JE, Argani P, Halushka MK, Thomson JA, Pharoah P, Porgador A, Sukumar S, Parsons R, Richardson AL, Stampfer MR, Gelman RS, Nikolskaya T, Nikolsky Y, Polyak K. Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14076-81. doi: 10.1073/pnas.0805206105. Epub 2008 Sep 9. PMID: 18780791; PMCID: PMC2532972.

  • Wu JM, Fackler MJ, Halushka MK, Molavi DW, Taylor ME, Teo WW, Griffin C, Fetting J, Davidson NE, De Marzo AM, Hicks JL, Chitale D, Ladanyi M, Sukumar S, Argani P. Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases. Clin Cancer Res. 2008 Apr 1;14(7):1938-46. doi: 10.1158/1078-0432.CCR-07-4082. PMID: 18381931; PMCID: PMC2965068.

  • Shipitsin M, Campbell LL, Argani P, Weremowicz S, Bloushtain-Qimron N, Yao J, Nikolskaya T, Serebryiskaya T, Beroukhim R, Hu M, Halushka MK, Sukumar S, Parker LM, Anderson KS, Harris LN, Garber JE, Richardson AL, Schnitt SJ, Nikolsky Y, Gelman RS, Polyak K. Molecular definition of breast tumor heterogeneity. Cancer Cell. 2007 Mar;11(3):259-73. doi: 10.1016/j.ccr.2007.01.013. PMID: 17349583.


Melanomas +
  • Makohon-Moore AP, Lipson EJ, Hooper JE, Zucker A, Hong, J, Bielski, CM, Hayashi A, Tokheim C, Baez P, Kappagantula R, Kohutek Z, Makarov V, Riaz N. Postow MA, Chapman PB, Karchin R, Socci ND, Solit DB, Chan TA, Taylor BS, Topalian SL, Iacobuzio-Donahue,CA The genetic evolution of treatment-resistant cutaneous, acral and uveal melanomas Clin Cancer Res 2020 December 15 DOI: 10.1158/1078-0432.CCR-20-2984


Neuropathology +
  • Taylor IC, Hütt-Cabezas M, Brandt WD, Kambhampati M, Nazarian J, Chang HT, Warren KE, Eberhart CG, Raabe EH. Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition. J Neuropathol Exp Neurol. 2015 Aug;74(8):778-90. doi: 10.1097/NEN.0000000000000216. PMID: 26115193; PMCID: PMC4596247.

  • Grasso CS, Tang Y, Truffaux N, Berlow NE, Liu L, Debily MA, Quist MJ, Davis LE, Huang EC, Woo PJ, Ponnuswami A, Chen S, Johung TB, Sun W, Kogiso M, Du Y, Qi L, Huang Y, Hütt-Cabezas M, Warren KE, Le Dret L, Meltzer PS, Mao H, Quezado M, van Vuurden DG, Abraham J, Fouladi M, Svalina MN, Wang N, Hawkins C, Nazarian J, Alonso MM, Raabe EH, Hulleman E, Spellman PT, Li XN, Keller C, Pal R, Grill J, Monje M. Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nat Med. 2015 Jun;21(6):555-9. doi: 10.1038/nm.3855. Epub 2015 May 4. Erratum in: Nat Med. 2015 Jul;21(7):827. PMID: 25939062; PMCID: PMC4862411.


Pancreatic Cancer +
  • Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, Kamiyama M, Hruban RH, Eshleman JR, Nowak MA, Velculescu VE, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature. 2010 Oct 28;467(7319):1114-7. doi: 10.1038/nature09515. PMID: 20981102; PMCID: PMC3148940.

  • Iacobuzio-Donahue CA, Fu B, Yachida S, Luo M, Abe H, Henderson CM, Vilardell F, Wang Z, Keller JW, Banerjee P, Herman JM, Cameron JL, Yeo CJ, Halushka MK, Eshleman JR, Raben M, Klein AP, Hruban RH, Hidalgo M, Laheru D. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol. 2009 Apr 10;27(11):1806-13. doi: 10.1200/JCO.2008.17.7188. Epub 2009 Mar 9. PMID: 19273710; PMCID: PMC2668706.


Pediatric Cancers +
  • Alabran JL, Hooper JE, Hill M, Smith SE, Spady KK, Davis LE, Peterson LS, Malempati S, Ryan CW, Acosta R, Spunt SL, Keller C. Overcoming autopsy barriers in pediatric cancer research. Pediatr Blood Cancer. 2013 Feb;60(2):204-9. doi: 10.1002/pbc.24320. Epub 2012 Sep 26. PMID: 23015377; PMCID: PMC3522778.


Prostate Cancer +
  • Zarif JC, Baena-Del Valle JA, Hicks JL, Heaphy CM, Vidal I, Luo J, Lotan TL, Hooper JE, Isaacs WB, Pienta KJ, De Marzo AM. Mannose Receptor-positive Macrophage Infiltration Correlates with Prostate Cancer Onset and Metastatic Castration-resistant Disease. Eur Urol Oncol. 2019 Jul;2(4):429-436. doi: 10.1016/j.euo.2018.09.014. Epub 2018 Oct 19. PMID: 31277779; PMCID: PMC7039332.

  • Maynard JP,Ertunc O,Kulac I,Baena-Del Valle JA,De Marzo AM,Sfanos KS. IL8 Expression Is Associated with Prostate Cancer Aggressiveness and Androgen Receptor Loss in Primary and Metastatic Prostate Cancer. Mol Cancer Res. 2020 Jan;18(1):153-165. doi: 10.1158/1541-7786.MCR-19-0595. PubMed PMID: 31604846;

  • Porter LH,Lawrence MG,Wang H,Clark AK,Bakshi A,Obinata D,Goode D,Papargiris M,Mural,Clouston D,Ryan A,Norden S,Corey E,Nelson PS,Isaacs JT,Grummet J,Kourambas J,Sandhu S,Murphy DG,Pook D,Frydenberg M,Taylor RA,Risbridger GP. Establishing a cryopreservation protocol for patient-derived xenografts of prostate cancer. Prostate. 2019 Aug;79(11):1326-1337. doi: 10.1002/pros.23839. PubMed PMID: 31212368.

  • Porter CM,Haffner MC,Kulac I,Maynard JP,Baena-Del Valle JA,Isaacs WB,Yegnasubramanian S,De Marzo AM,Sfanos KS. Lactoferrin CpG Island Hypermethylation and Decoupling of mRNA and Protein Expression in the Early Stages of Prostate Carcinogenesis. Am J Pathol. 2019 Nov;189(11):2311-2322. doi: 10.1016/j.ajpath.2019.07.016. PubMed PMID: 31499027; PMCID: PMC6892185.

  • Brennen WN,Isaacs JT. Mesenchymal stem cells and the embryonic reawakening theory of BPH. Nat Rev Urol. 2018 Nov;15(11):703-715. doi: 10.1038/s41585-018-0087-9. PubMed PMID: 30214054; PMCID: PMC7050678.

  • Brennen WN, Isaacs JT. The what, when, and why of human prostate cancer xenografts. Prostate. 2018 Jun;78(9):646-654. doi: 10.1002/pros.23510. PubMed PMID: 29575112.

  • Navone NM,van Weerden WM,Vessella RL,Williams ED,Wang Y,Isaacs JT,Nguyen HM,Culig Z,van der Pluijm G,Rentsch CA,Marques RB,de Ridder CMA,Bubendorf L,Thalmann GN,Brennen WN,Santer FR,Moser PL,Shepherd P,Efstathiou E,Xue H,Lin D,Buijs J,Bosse T,Collins A,Maitland N,Buzza M,Kouspou M,Achtman A,Taylor RA,Risbridger G,Corey E. Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient-derived xenograft (PDX) models. Prostate. 2018 Dec;78(16):1262-1282. doi: 10.1002/pros.23701. PubMed PMID: 30073676.

  • Haffner MC, De Marzo AM, Yegnasubramanian S, Epstein JI, Carter HB. Diagnostic challenges of clonal heterogeneity in prostate cancer. J Clin Oncol. 2015 Mar 1;33(7):e38-40. doi: 10.1200/JCO.2013.50.3540. Epub 2014 Mar 17. PMID: 24638011.

  • Yu SH,Zheng Q,Esopi D,Macgregor-Das A,Luo J,Antonarakis ES,Drake CG,Vessella R,Morrissey C,De Marzo AM,Sfanos KS. A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells. Cancer Immunol Res. 2015 Oct;3(10):1175-84. doi: 10.1158/2326-6066.CIR-15-0013. PubMed PMID: 26048576; PMCID: PMC4596748.

  • Antonarakis ES, Nakazawa M, Luo J. Resistance to androgen-pathway drugs in prostate cancer. N Engl J Med. 2014 Dec 4;371(23):2234. doi: 10.1056/NEJMc1412594. PMID: 25470700.

  • Cimino-Mathews A., et al. GATA3 expression in breast carcinoma: utility in triple-negative, sarcomatoid, and metastatic carcinomas. Hum Pathol. 2013 Jul;44(7):1341-9. PMID: 23375642.

  • Aryee MJ, Liu W, Engelmann JC, Nuhn P, Gurel M, Haffner MC, Esopi D, Irizarry RA, Getzenberg RH, Nelson WG, Luo J, Xu J, Isaacs WB, Bova GS, Yegnasubramanian S. DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases. Sci Transl Med. 2013 Jan 23;5(169):169ra10. doi: 10.1126/scitranslmed.3005211. PMID: 23345608; PMCID: PMC3577373.


Sarcomas +
  • Bharathy N,Berlow NE,Wang E,Abraham J,Settelmeyer TP,Hooper JE,Svalina MN,Bajwa Z,Goros MW,Hernandez BS,Wolff JE,Pal R,Davies AM,Ashok A,Bushby D,Mancini M,Noakes C,Goodwin NC,Ordentlich P,Keck J,Hawkins DS,Rudzinski ER,Mansoor A,Perkins TJ,Vakoc CR,Michalek JE,Keller C. Preclinical rationale for entinostat in embryonal rhabdomyosarcoma. Skelet Muscle. 2019 May 21;9(1):12. doi: 10.1186/s13395-019-0198-x. PubMed PMID: 31113472; PMCID: PMC6528217.

  • Bharathy N, Berlow NE, Wang E, Abraham J, Settelmeyer TP, Hooper JE, Svalina MN, Ishikawa Y, Zientek K, Bajwa Z, Goros MW, Hernandez BS, Wolff JE, Rudek MA, Xu L, Anders NM, Pal R, Harrold AP, Davies AM, Ashok A, Bushby D, Mancini M, Noakes C, Goodwin NC, Ordentlich P, Keck J, Hawkins DS, Rudzinski ER, Chatterjee B, Bächinger HP, Barr FG, Liddle J, Garcia BA, Mansoor A, Perkins TJ, Vakoc CR, Michalek JE, Keller C. The HDAC3-SMARCA4-miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma. Sci Signal. 2018 Nov 20;11(557):eaau7632. doi: 10.1126/scisignal.aau7632. PMID: 30459282; PMCID: PMC6432638.

  • Kikuchi K, Wettach GR, Ryan CW, Hung A, Hooper JE, Beadling C, Warrick A, Corless CL, Olson SB, Keller C, Mansoor A. MDM2 amplification and PIK3CA mutation in a case of sclerosing rhabdomyosarcoma. Sarcoma 2013;2013:520858. PMID: 23766666.

  • Hooper JE, Cantor EL, Ehlen MS, Banerjee A, Malempati S, Stenzel P, Woltjer RL, Gandour-Edwards R, Goodwin NC, Yang Y, Kaur P, Bult CJ, Airhart SD, Keller C. A Patient-Derived Xenograft Model of Parameningeal Embryonal Rhabdomyosarcoma for Preclinical Studies. Sarcoma. 2015;2015:826124. doi: 10.1155/2015/826124. Epub 2015 Nov 30. PMID: 26696773; PMCID: PMC4677247.


Urinary +
  • Gorin MA, Rowe SP, Hooper JE, Kates M, Hammers HJ, Szabo Z, Pomper MG, Allaf ME. PSMA-Targeted 18F-DCFPyL PET/CT Imaging of Clear Cell Renal Cell Carcinoma: Results from a Rapid Autopsy. Eur Urol. 2017 Jan;71(1):145-146. doi: 10.1016/j.eururo.2016.06.019. Epub 2016 Jun 28. PMID: 27363386; PMCID: PMC5516900.


Other Disease +
  • Crnkovic S, Egemnazarov B, Damico R, Marsh LM, Nagy BM, Douschan P, Atsina K, Kolb TM, Mathai SC, Hooper JE, Ghanim B, Klepetko W, Fruhwald F, Lassner D, Olschewski A, Olschewski H, Hassoun PM, Kwapiszewska G. Disconnect between Fibrotic Response and Right Ventricular Dysfunction. Am J Respir Crit Care Med. 2019 Jun 15;199(12):1550-1560. doi: 10.1164/rccm.201809-1737OC. PMID: 30557518; PMCID: PMC6580669.