Featured Publications
Our department's impact on pathology research is evident: Johns Hopkins Pathology has been the #1 NIH-funded pathology department for 15 of the past 17 years. Below are recent highlighted publications from our department.
3D Genomic Mapping Offers New Insight into Pancreatic Precancers
The study investigates pancreatic intraepithelial neoplasias (PanINs), which are precursors to pancreatic cancer, through advanced 3D genomic mapping techniques. Analyzing 46 large samples of normal human pancreas, the researchers employed a machine-learning pipeline for detailed histological reconstruction at single-cell resolution. They discovered an average of 13 PanINs per cm³, suggesting that the normal pancreas may contain hundreds of these...
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Gene Variants Enhance Diagnostic Accuracy of Pancreatic Cancer Tumor Markers
This study found that a FUT2/FUT3 tumor marker gene test to predict an individual’s capacity to synthesize the circulating tumor markers CA19-9 and DUPAN-2 significantly improved their diagnostic performance for detecting cases with stage I/II pancreatic cancer versus controls with familial/genetic risk undergoing pancreatic surveillance. The gene test is used to personalize the reference ranges of CA19-9 and DUPAN-2 and improves diagnostic sen...
Read MoreClues for Immunotherapy Options in Intimal Sarcoma
Intimal sarcomas are rare, aggressive soft tissue tumors for which there are limited effective treatment options. Immunomodulatory therapy, particularly targeting of the PD-1/PD-L1 axis has revolutionized the field of oncology and become a cornerstone of treatment for some solid tumors, but remains exploratory in most sarcomas. Most large trials for immunotherapy in sarcomas do not include many intimal sarcomas due to their rarity. We sought to i...
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In the Spotlight: Novel Cytokine Signature Discovered in Bladder Cancer
Cytokines are known to be a key factor in numerous malignancies and exert an important regulatory role in the tumor microenvironment. Interest has grown in understanding how cytokines modulate the tumor microenvironment and which cytokines may serve as markers of the tumor process; however, a complete picture of the cytokine landscape in bladder cancer remains unclear. Our study measured the concentrations of four cytokines present in the urine o...
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