Featured Publications
Our department's impact on pathology research is evident: Johns Hopkins Pathology has been the #1 NIH-funded pathology department for 15 of the past 17 years. Below are recent highlighted publications from our department.
Leveraging Multi-Omics to Advance the Stratification of Intraductal Papillary Neoplasms of Pancreas
Intraductal papillary mucinous neoplasms are non-invasive precancerous lesions of the pancreas. They can be detected on imaging, but when they are, they present a significant clinical dilemma. While surgically resecting them would prevent them from progressing to cancer, not all IPMNs do progress to cancer, and surgery on the pancreas is associated with significant morbidity. Yuefan Wang and colleagues studied the patterns of expression of a la...
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Double Duty for Neurons : Sensing and Stimulating Bone Repair
The profound pain accompanying bone fracture is mediated by somatosensory neurons, yet their roles in tissue repair are largely unknown. To characterize neuroanatomical circuitry mediating skeletal nociception and regeneration, the James lab profiled dorsal root ganglia (DRG) neurons innervating murine long bones by retrograde nerve labeling and single-cell transcriptomics before and after experimental fracture. Their findings reveal a diverse r...
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Big Data Enhances Longitudinal Biomarker Discovery
AstroID is a scalable database that integrates diverse cancer data—including lab results, genetic sequencing, imaging, and specimen details—into a single, queryable framework. Organized in six hierarchical tiers covering deidentified patient information, diagnoses, clinical events, specimens, lab processing, and individual slides or aliquots, AstroID allows longitudinal analysis across multiple tumor types and patient cohorts. Built on the REDCap...
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Emerging Trends: Methamphetamine-Opioid Injection on the Rise
While synthetic opioids in illicit drug markets have fueled high overdose rates and contributed to HIV and hepatitis C virus outbreaks among people who inject drugs (PWID) in the US, overdose deaths involving psychostimulants—particularly methamphetamine—have increased sharply, often in combination with opioids. Stimulant injection is associated with greater injection frequency, syringe sharing, and elevated infectious disease risk, yet national ...
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