Ordering Information

Epic Orderable Name:  FISH B-Cell ALL Panel

Epic Test Id:  LAB20362

Testing Includes:  See Mayo Clinic website for additional information.

     The Standard (diagnostic) B-ALL FISH panel includes testing for the following abnormalities, using the FISH probes listed:
 

initial (diagnostic) adult

• t(9;22)(q34;q11.2), BCR/ABL1 fusion, BCR/ABL1 D-FISH
  t(X;14)(p22.33;q32)/ t(Y;14)(p11.32;q32), CRLF2/IGH

If results for initial panel are negative or demonstrate non classical abnormalities, the Philadelphia chromosome-like accute lymphoblastic Leukemia panel will be performed as a secondary panel:

• 1q25 rearrangement, ABL2 break-apart

• 5q32 rearrangement, PDGFRB break-apart

• 9p24.1 rearrangement, JAK2 break-apart

• 9q34 rearrangement, ABL1 break-apart

• t(Xp22.33;var) or t(Yp11.32;var) rearrangement, CRLF2 break-apart

• t(Xp22.33;var) or t(Yp11.32;var) rearrangement, P2RY8 break-apart

If results for the Ph-like panel are negative or demonstrate nonclassical abnormalities, the following probe sets will be performed as a tertiary panel:

• t(1;19)(q23;p13), PBX1/TCF3

• Hyperdiploidy, +4,+10,+17, D4Z1/D10Z1/D17Z1

• t(12;21)(p13;q22) or iAMP21, ETV6/RUNX1

• 14q32 rearrangement, IGH break-apart

• 11q23 rearrangement, MLL(KMT2A) break-apart

• 7p-, IKZF1/CEP7

Aliases:  FISH B-CELL ALL Oncology Cancer Cytogenomics Cytogenetics

Testing Schedule:  Monday thru Friday

Turnaround Time:  7-14 Days

Order Priorities:  Routine

Performing Laboratory:  Mayo Clinic Labs

LOINC:  62369-4

Methodology:  Fluorescence Insitu Hybridization (FISH)

Ordering Restrictions:  Note: this test will be sent out to Mayo Clinic Laboratories.  The interpretive report will be placed in epic

Reference Lab Test Code:  BALAF (adults) BALPF (pediatric)
Link to Mayo test catalog: https://www.mayocliniclabs.com/test-catalog

Specimen Requirements

Collection Container:  Green Top Tube - Sodium Heparin

Collection Volume:  2-3 mL

Minimum Volume:  1.0 mL

Specimen Stability:  Store room temperature (preferred), may be refrigerated. DO NOT FREEZE

Specimen Types:  Bone marrow

For Lab Staff

Performing Lab:  Mayo Clinic Labs

LAB phone:  410-955-1258; specimens will be received M-F, between 8am and 4pm; Saturday's limited coverage; leave voice mail

Lab Notes

     - Test is performed by Mayo Clinic Laboratories. 
     - For send out, send to tube station 072 
     - Results in EPIC under Lab Results

     - Lab specimen shipping address:
          Johns Hopkins Cytogenomics/Cytogenetics Lab
          deliver to Johns Hopkins Core Lab
          600 N Wolfe Street
          Baltimore, MD 21287

     - Downtime - use Pathology 14 form