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Prognostic Value of Modified Oxford Score for Post-Transplant Recurrent IgA Nephropathy

This study examines the prognostic usefulness of the Oxford classification/MEST-C score (Mesangial and Endocapillary hypercellularity, Segmental sclerosis, Tubular atrophy-interstitial fibrosis, and the presence of Crescents) in biopsies of recurrent immunoglobulin A nephropathy (IgAN) in a North America multicenter study.

The results show that higher MEST-C scores are associated with higher risks of graft failure (adjusted hazard ratio 8.57 for score sums 2-3, and 61.32 for score sums 4-5, versus 0), and validate data obtained in an Asian cohort.

The findings support the prognostic usefulness of the Oxford classification for recurrent IgAN and the inclusion of the MEST-C score in allograft biopsies diagnostic reports.

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