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Laboratory Tests & Services
Laboratory tests/services include:
- Bone marrow engraftment assays
- Next generation sequencing (NGS) panels for solid tumors and hematologic malignancies
- Microsatellite instability testing
- Quantitative BCR/ABL RT-PCR
- Translocation assays for leukemias and soft tissue tumors
- IGH and TCR rearrangement for B-cell and T-cell clonality
- Molar pregnancy genotyping
- Telomere length measurement by flow cytometry and FISH
Contact
Hours of Operation: Monday-Friday: 8:30AM - 5:30PM (closed on weekends and holidays)
Phone: 410-955-8363
Email: [email protected]
Address:
Johns Hopkins Genomics - MDL
1812 Ashland Avenue
Room 245
Baltimore, MD 21205
Lab Staff
| Directors | Drs. Rena Xian, Christopher Gocke, Ming-Tseh Lin, James Eshleman, and Jonathan Dudley |
| Telomere Length Assay | Dr. Mary Armanios |
| Manager | Trisha James |
| Clinical Specialists (Assay Development) | Jing Zhu and Thomas Hebert |
| Lead Technologists | Kirstin Smith and Emily Adams |
| Genetic Analysts | Suping Chen, Zhimin Xiang, and Marie Valerie Toure |
| Bioinformatics | Aparna Pallavajjalla, Shweta Jones, and Vrshank Raviveeraraghavan |
| Technologists | Chrisley Pickens, Jake Anderson, Jormoh Bellepu, Kerri Magerowski, Kiana Coche, Klarissa Juliano, Lauren Mulcahy, Louis Randall, Tiffany Anyanwu, Ty Power, Wendell Alejo, Christina Cuzzi, Justina Ofosu, Rick Weilminster, Christopher Avergas and Sainkhuu Enkh-Otgon |
Shipping Instructions
The Molecular Diagnostics Laboratory is CAP and CLIA-certified and is licensed in Maryland, Pennsylvania, Florida, and New York (for Telomere Length testing only).
- Please ship each specimen with a completed requisition form, including payment information.
- Telomere Flow FISH Requisition Form
TeloZoom sequencing is offered through the Johns Hopkins DNA Diagnostic Laboratory.
If interested in ordering this test, please find details here. - Molecular Diagnostics Lab Requisition Form for all other tests.
- Telomere Flow FISH Requisition Form
- For tissue specimens, include a copy of the surgical pathology report.
- All specimens must be labeled with at least two patient identifiers (such as patient name, date of birth, or medical record number) which match the information on the accompanying documents.
- See sample-specific shipping requirements below this page for - Blood and Bone Marrow, FFPE Tissue, and Buccal Swabs
- Before shipping, please call the lab at 410-955-1438 or email [email protected] with any questions and to notify us of the shipment.
Shipping Address
Johns Hopkins Genomics - MDL
1812 Ashland Avenue
Room 245
Baltimore, MD 21205
Schedule
The lab is not able to accept deliveries on Saturdays or the following holidays (or observed holidays): New Year's Day, MLK Jr Day, Memorial Day, Juneteenth, Independence Day, Labor Day, Thanksgiving Day, Christmas Day.
Specimen Requirements
Please see the Test Menu for specimen requirements for specific tests.
Blood and Bone Marrow
A. For Telomere Flow FISH, keep specimens at room temperature, and ship overnight. Specimen requirements are:
- Adults: 12-18 cc in yellow top ACD tubes.
- Infants and children: Minimum 3 cc in lavender top EDTA tube.
- Samples will be rejected if blood tubes are not filled properly, if blood is received >72 hours of collection, or if blood was not stored at room temperature.
B. For all other tests, lavender top EDTA tubes are preferred. Refrigerate and ship overnight with cold pack. Do not freeze.
FFPE Tissue
- Include a copy of the surgical pathology report with the specimen.
- Blocks to be tested must contain tumor tissue. For Microsatellite Instability testing, normal tissue is also required. If no block containing Normal tissue is available, please submit blood or a buccal swab from the patient.
- FFPE tissue may be submitted as slides (preferred) or blocks.
- If slides are submitted:
- Slides should be cut with PCR precautions.
- H&E slides should be adjacent to unstained slides in series.
- Please see the Test Menu for number of slides required for specific tests.
- Package slides in appropriate containers to prevent breakage.
- These specimens may be shipped at ambient temperature.
Buccal Swabs
- Buccal swabs may be submitted for patient and/or donor for BMT Comprehensive testing and for Normal tissue for Microsatellite Instability testing.
- These specimens may be shipped at ambient temperature.
DNA
Extracted DNA is accepted as a specimen type under certain circumstances, either following specific request and consultation with the lab director, or for Pre-BMT specimens not otherwise obtainable. In these instances, the extraction must be performed in a CLIA-certified laboratory or a laboratory meeting equivalent (or more stringent) requirements as determined by the College of American Pathologists (CAP) and/or the Centers for Medicare and Medicaid Services (CMS).