26th Annual Young Investigators' Day - Poster Session
TUESDAY, MARCH 12, 2024
TURNER CONCOURSE
Presentation Details
PURPOSE
The goal of this event is to provide a forum for scientific and personal interactions between trainees and faculty in the divisions and laboratories of the Department of Pathology. This event will highlight the high quality and variety of research training and research being performed in our department and will foster a sense of mutual interest and purpose.
ELIGIBILITY
Any fellow or resident who has presented or will be presenting their work in any format at a national meeting between April, 2023, and March, 2024 is required to present. All Pathology/Pathobiology Trainees are strongly encouraged to participate! Preliminary or published data in the areas of Basic Research, Translational Research and Clinical Research may be presented.
PRESENTATIONS
*NOTE: There is a limit of 1 poster/abstract presentation permitted per presenter, however a second may be permitted with written permission from Stacey March or a PYID Director. Poster size is limited to 4’ x 8’. Easels and poster boards will be available for display purposes. Posters must be set up before 9:45 am on Tuesday, March 12th. A panel of faculty judges will conduct an open review and discuss posters with presenters between 10:00am and 3:30p.m, with our guest speaker presenting at Noon.
Presenters: Please plan to bring tacks, clips, etc. to attach your posters to the boards provided.
GUEST SPEAKER
Beginning at noon in the Tilghman Auditorium, our guest speaker, Ted M. Dawson, M.D., Ph.D., Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases; Director, Institute for Cell Engineering; Professor, Departments of Neurology, Neuroscience and Pharmacology & Molecular Sciences at the Johns Hopkins University School of Medicine, will give a research presentation. If you are available, we would ask that you kindly plan to attend the lecture.
AWARDS
Upon recommendation of the panel of faculty judges, a prize for outstanding scientific contributions in clinical research, translational research, and in basic research will be awarded to the individuals whose presentations are judged to be the most outstanding examples of high-quality research and excellent presentation. A cash prize will be presented to the winners and their achievements will be announced at a Pathology Awards Ceremony to honor our awarded presentations on Wednesday, June 12, 2024 (more details to be announced by the Path Training Office).
Presentation Schedule
10:00 a.m. — 11:45 a.m. (Session One)
Judges review and discuss posters with presenters.
12:00 noon — 1:00 p.m.
Ted Dawson, M.D., Ph.D. (Lecturer)
Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases
Director, Institute for Cell Engineering
Professor, Departments of Neurology, Neuroscience and Pharmacology & Molecular Sciences
Johns Hopkins University School of Medicine
Lecture Title: TBA
1:00 p.m. — 1:30 p.m.
Boxed lunches served in concourse
1:30 p.m. — 3:00 p.m. (Session Two)
Judges review and discuss posters with presenters.
3:30 p.m. — 4:00 p.m.
Judges and presenters wrap up discussions and posters are taken down.
Awards
Below are the awards for the 25th Annual Department of Pathology Young Investigators' Day - March 28, 2023
Excellence in Basic Research
Top Presenter: Nianbin (Nelson) Song, Ph.D.
| Presenter | Title | Division | Authors | Poster Title |
|---|---|---|---|---|
| Nianbin (Nelson) Song, Ph.D. | Research Fellow | Immunopathology | Nianbin Song, Robin Welsh, Scheherazade Sadegh-Nasseri | Loss of HLA-DO function impairs the development of memory CD4 T cells |
| Jesus Contreras Rodriguez, B.Sc. | Grad Student (MMI) | Immunopathology | Jesús Contreras Rodríguez, Adrian Martin Esteban, David Peske, Nilabh Shastri, Scheherazade Sadegh-Nasseri | Decrypting pMHCI Diversity Through Noncanonical Translation Initiation |
| David M. Hughes, B.S. | Grad Student (BME) | Immunopathology | David M. Hughes, Taejoon Won, Monica V. Talor, Hannah M. Kalinoski, Ivana Jurčová, Ondrej Szárszoi, Ilja Stříž, Lenka Čurnová, William Bracamonte-Baran, Vojtěch Melenovský, Daniela Čiháková | GATA6+ Pericardial Macrophages Protect Pericardium but not Myocardium from Inflammation |
| Hannah M. Kalinoski, B.S., B.A. | Grad Student (MMI) | Immunopathology | Hannah Kalinoski, Taejoon Won, Abdel Daoud, Vitali Rusinkevich, Ivana Jurčová, Monica Vladut Talor, David Hughes, Ondrej Szrászoi, Lenka Čurnova, Ilja Stříž, Jody E. Hooper, Vojtěch Melenovský, Daniela Čiháková | Cardiac Injury Induced Myosin specific TRM cells Drive Immune Checkpoint Inhibitor Myocarditis |
| Adrian Martin-Esteban, Ph.D. | Research Fellow | Immunopathology | Martín-Esteban, Adrian, Ph.D., Contreras Rodriguez, Jesus, B.Sc., Peske David J., M.D., Ph.D., Jose A. Lopez de Castro Ph.D., Shastri, Nilabh, Ph.D., and Sadegh-Nasseri, Scheherazade, Ph.D. | The ER Aminopeptidases, ERAP1 and ERAP2, Synergize to Self-Modulate their Respective Activities |
| Dongseok Park, Ph.D. | Research Fellow | Neuropathology | Dongseok Park, Jennifer K. Lee, Lee J. Martin | Cholecystokinin (CCK) Signaling as a Possible Mechanism in the Injury Response of Cerebral Cortex in a Novel Translationally-Relevant Porcine Model of Neonatal Hypoxic-Ischemic Encephalopathy |
Excellence in Clinical Research
Top Presenters: Taejoon Won, Ph.D. & Thomas D. Zaikos, M.D., Ph.D.
| Presenter | Title | Division | Authors | Poster Title |
|---|---|---|---|---|
| Taejoon Won, Ph.D. | Research Fellow | Immunopathology | Taejoon Won, Hannah M. Kalinoski, Megan K. Wood, David M. Hughes, Camille M. Jaime, Paul Delgado, Monica V. Talor, Ninaad Lasrado, Jay Reddy, Daniela Čiháková | Cardiac myosin-specific autoimmune T cells contribute to the development of immune-checkpoint-inhibitor-associated myocarditis |
| Thomas D. Zaikos, M.D., Ph.D. | Housestaff | Neuropathology | Thomas D. Zaikos, Mohammad Salimian, Meaghan Morris, Heather Ames, Cinthia Drachenberg, John C. Papadimitriou, Julia V Hegert, Cheng-Ying Ho | Postmortem Assessment of Olfactory Tissue Injury and Microvasculopathy Associated with SARS-CoV-2 Variants |
| Annie Wu, M.D., Ph.D. | Housestaff | Neuropathology | Annie A. Wu, Kevin Y. Zhang, Tara Srinivas, Joshua D. Materi, Christopher J. VandenBussche, Thomas Zaikos, Cheng-Ying Ho | Neuropathologic Features and Underlying Medical Disease States of Spontaneous Subdural Hematomas in Adults: A Hospital Autopsy Case Series from a Single Tertiary Center |
Excellence in Translational Research
Top Presenter: Katie Irwin, B.S.
| Presenter | Title | Division | Authors | Poster Title |
|---|---|---|---|---|
| Katie Irwin, B.S. | Grad Student (Neuroscience) | Neuropathology | Katherine E. Irwin, Pei Jasin, Kerstin E. Braunstein, Irika Sinha, Kyra D. Bowden, Abhay Moghekar, Esther S. Oh, Denitza Raitcheva, Dan Bartlett, James D. Berry, Bryan Traynor, Jonathan P. Ling, and Philip C. Wong | A fluid biomarker reveals loss of TDP-43 splicing repression in pre-symptomatic ALS |
| Rafid Al-Hallaf, Ph.D. | Research Fellow | Immunopathology | Rafid Al-Hallaf, Rizwan Ahmed, Zainab Agha, Adil Karim, Joseph Heinemann, Prajita Paul, Neha Majety, Thomas Donner, and Abdel Rahim A. Hamad | A germline-encoded autoantibody - T cell axis in type 1 diabetes |
| Niklas Bachmann, B.Sc. | Grad Student (Pathobiology) | Medicine - Immunology and Infectious Diseases | Niklas Bachmann, Srona Sengupta, Robert F. Siliciano | Targeting HIV-infected cells for immunotherapy through HLA-E |
| Stephen Brown, B.S. | Grad Student (Pathobiology) | Neurology | Stephen Brown, Daniel Ramos, Constantin d’Ydewalle, Charlotte Sumner | Targeting the lncRNA SMN-AS1 as a potential therapy for SMA |
| Jiayu Chen, Ph.D. | Research Fellow | GU Pathology | Jiayu Chen; Qizhi Zheng; Jessica L. Hicks; Levent Trabzonlu; Rulin Wang; Alan K.Meeker; Emmanuel S Antonarakis; Samuel R Denmeade; Mark C Markowski; Srinivasan Yegnasubramanian; Angelo M. De Marzo | An in situ approach reveals increased mitochondrial DNA copy number and mitochondrial gene expression in prostate cancer |
| Masnsen Cherief, Ph.D. | Research Fellow | Surgical Pathology | Masnsen Cherief, Jiajia Xu, Zhao Li,Stefano Negri, Mario Gomez-Salazar, Cammy Tang, Sowmya Ramesh, Lingke Zhong, Robert Tower, Benjamin Levi, Aaron W. James | Skeletal nerves modulate tendon sheath progenitor cell proliferation during tendon repair via TGFβ signaling |
| Jun (Tony) Choe, B.S. | Grad Student (Pathobiology) | Oncology | Jun Choe, Sachiv Chakravarti, Natalie Holl, Arjun Modi, Ruyan Rahnama, Stamatia Vorri, Eric H. Raabe, Challice L. Bonifant | Anti-B7H3 Chimeric Antigen Receptor NK cells for high-risk pediatric brain tumors |
| Logan George, B.S. | Grad Student (Pathobiology) | Oncology | Logan George, Lisa Haley, Prisca Mbonu, Jennifer Petr, Samantha Vogt, Rena R. Xian, & Richard Ambinder | Epstein-Barr Virus C promoter methylation serves as a biomarker for EBV-associated cancers |
Past Years' Awards
2022
24th Annual Department of Pathology Young Investigators' Day - March30, 2022 (Virtual Event)
Top Three Presenters in their Category
- Basic: Diego Lema, M.D., Ph.D.
- Clinical: Harsimar Kaur, MBBS
- Translational: Liwei Cao, Ph.D.
Excellence in BASIC RESEARCH
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Diego Lema, M.D., Ph.D. | Research Fellow | Immunopathology | Daniela Čiháková, M.D., Ph.D. | A monoclonal antibody blocking IL-1 receptor accessory protein reduces acute viral myocarditis severity |
| Yunong Bai | Undergraduate Student (Biomedical Engineering) | Neuropathology | David W. Nauen, M.D., Ph.D. | Harnessing tissue clearing and machine vision to identify changes in human hippocampal microcirculation in Alzheimer’s disease |
| Chan-Su Park, Ph.D. | Research Fellow | Immunopathology | Scheherazade Sadegh-Nasseri, Ph.D. | Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes |
| J. David Peske, M.D., Ph.D. | Immunopathology | Scheherazade Sadegh-Nasseri, Ph.D.; Chun Jimmie Ye, Ph.D. | Selection of a common ERAP2 haplotype elicits antigenic viral responses | |
| Cornelia Peterson, DVM, Ph.D. | Research Fellow | Charles G. Eberhart, M.D., Ph.D. | Contribution of MYC copy number gain and mutations in tumor suppressor genes to the oncogenesis of ocular adnexal sebaceous carcinomas | |
| Monali Praharaj, B.S. | Jelani C. Zarif, M.S., Ph.D. | Glutamine blockade via prodrug JHU083 reprograms immunosuppressive tumor associated macrophages (TAMs) and drives tumor immunity in urologic cancers | ||
| Nianbin (Nelson) Song, Ph.D. | Research Fellow | Immunopathology | Scheherazade Sadegh-Nasseri, Ph.D. | Investigating a role for HLA-DO in the development of CD4 Memory cells |
| Robin Welsh, Ph.D. | Research Fellow | Immunopathology | Scheherazade Sadegh-Nasseri, Ph.D. | HLA-DO promotes Treg differentiation by altering thymic antigen presentation |
Excellence in Clinical Research
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Harsimar Kaur, MBBS | Housestaff | Surgical Pathology | Marissa J. White, M.D. | Clinical Pathology Web Unknowns: A Case-Based Repository of Core CP Teaching Points |
| Michael Mikula, M.D. | Housestaff | GI/Liver Pathology | Lisa M. Rooper, M.D. | Sinonasal High Grade Neuroendocrine Carcinomas: A Clinicopathological and Immunohistochemical Re-Appraisal |
| Taejoon Won, Ph.D. | Research Fellow | Immunopathology | Daniela Čiháková, M.D., Ph.D. | Pericardial fluid CCR2+ macrophages promote tissue damage in patients with ischemic heart disease |
Excellence in Translational Research
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Liwei Cao, Ph.D. | Research Fellow | Clinical Chemistry | Hui Zhang, Ph.D. | Proteogenomic characterization of pancreatic ductal adenocarcinoma |
| Carli Jones, B.S. | Graduate Student (Pathobiology) | GU Pathology | Karen S. Sfanos, M.S., Ph.D. | The microbial metabolite equol as a radiosensitizer and therapeutic agent in prostate cancer |
| Kristen Malebranche, B.S. | Research Technician (Cell Biology) | Ophthalmology | Eric Raabe, M.D., Ph.D.; Jeffrey Rubens, M.D. | The PI3K inhibitor Paxalisib combines synergistically with the pan-Raf inhibitor TAK580 (DAY 101) to extend survival in orthotopic xenograft models of atypical teratoid/rhabdoid tumors |
| Puwanat ("A") Sangkhapreecha, B.S. | Graduate Student (Chemical and Biomolecular Engineering) | Immunopathology | H. Benjamin Larman, Ph.D. | Multiplexing of DNA-protein conjugation and its applications in protein-protein interaction studies |
| Yeh Wang, M.D. | Graduate Student (Pathobiology) | Gynecologic Pathology | Ie-Ming Shih, M.D., Ph.D. | Transcriptomic Analysis in Ovarian Cancer Precursors Reveals Reactivation of Insulin Growth Factor Binding Protein-2 in Pathogenesis |
2021
23rd Annual Department of Pathology Young Investigators' Day - March19, 2021 (Virtual Event)
Top Three Presenters in their Category
- Basic: Shaopeng Wang, Ph.D.
- Clinical: Gabrielle Bailey, M.D.
- Translational: Ariel Isser, B.S.
Excellence in BASIC RESEARCH
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Shaopeng Wang, Ph.D. | Research Fellow | Neuropathology | Shuying Sun, Ph.D. | Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD |
| Rizwan Ahmed, Ph.D. | Research Fellow | Immunopathology | Abdel Rahim A Hamad, M.V.Sc., Ph.D. | x-mAb produced by dual expresser lymphocytes identifies a universal autoreactive T cell receptor |
| Kusuma Ananth, B.A. | Graduate Student (Immunology) | Immunopathology | Abdel Rahim A Hamad, M.V.Sc., Ph.D. | Understanding the Role of a Novel Lymphocyte in the Pathogenesis of Multiple Sclerosis May Lead to New Specific Immunotherapy |
| Wei-Yu Chi, M.D. | Research Fellow | GYN Pathology | Chuan-Hsiang Huang, M.D., Ph.D. | Deciphering signaling network dynamics using massively multiplexed biosensor tracking in barcoded cells |
| Lionel Chia, M.Sc. | Graduate Student (Pathobiology) | Hematology | Linda M. S. Resar, M.D. | The High Mobility Group A1 Chromatin Remodeling Protein Induces FGF19 and Recruits Cancer-Associated Fibroblasts to Drive Tumor Progression in Pancreatic Ductal Adenocarcinoma |
| Ye Eun Jeong, Pharm.D. | Graduate Student (Pathobiology) | Neuropathology | Ahmet Höke, M.D., Ph.D. | Downregulated SF3B2 protects the Central Nervous System (CNS) neurons against inflammatory insult |
| Hannah Kalinoski, B.S. | Graduate Student (Molec Micro & Imm) | Immunology | Daniela Čiháková, M.D., Ph.D. | Myosin specific TRM cells mediate increased severity of immune checkpoint inhibitor myocarditis |
| Yini Li, Ph.D. | Research Fellow | Immunopathology | Shuying Sun, Ph.D. | Epitranscriptomic dysregulation in C9ORF72-ALS/FTD |
| Katie Marshall, B.S. | Graduate Student (Pathobiology) | Neurology | Mohamed H. Farah, Ph.D. | Examining Axonal Regeneration of ALS Patient IPSC-Derived Motor Neurons |
| Daniel Monaco, B.S. | Graduate Student (Pathobiology) | Immunopathology | H. Benjamin Larman, Ph.D. | Profiling serum antibodies with a pan allergen phage library identifies key wheat allergy epitopes |
| J. David Peske, M.D., Ph.D. | Housestaff | Immunopathology | Nilabh Shastri, Ph.D. | Regulation of Antigen Processing by Inflammation Induced Isoforms of ER Aminopeptidases |
| Megan Wood, B.S. | Graduate Student (Molec Micro & Imm) | Immunology | Daniela Čiháková, M.D., Ph.D. | Macrophage PD-L1 expression protects from severe collagen induced arthritis |
Excellence in Clinical Research
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Gabrielle Bailey, M.D. | Housestaff | Cytopathology | Erika F. Rodriguez, M.D., Ph.D. | The Value of Second Opinion Consultation in Non-Gynecologic Cytopathology |
Excellence in Translational Research
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Ariel Isser, B.S. | Graduate Student (Biomedical Engineering) | Immunopathology | Jonathan P. Schneck, M.D., Ph.D. | Artificial T Cell Help to Enhance Cancer Immunotherapy |
| Cherub O. Kim, M.D. | Housestaff | Clinical Chemistry | Zhen Zhang, Ph.D. | A More Statistically Robust Approach to Machine Learning Model Development and Validation under the Constraint of Small Datasets |
| Robert Kruse, M.D., Ph.D. | Housestaff | Transfusion Medicine | Aaron A.R. Tobian, M.D., Ph.D. | A point of care, semi-quantitative red blood cell agglutination assay for detecting antibodies against SARS-CoV-2 |
2020
22nd Annual Department of Pathology Young Investigators' Day - May 2020
Top Three Presenters in their Category
- Basic: Mohanraj Sadasivam, Ph.D.
- Clinical: John Lin, B.S.
- Translational: David Clark, Ph.D.
Excellence in BASIC RESEARCH
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Mohanraj Sadasivam, Ph.D. | Res Fellow | Immunopathology | Abdel Rahim A Hamad, DVM, Ph.D. | A mutually beneficial relationship between double-negative (DN) T cells and renal epithelial cells explains selective accumulation of DN T cells in the kidney |
| Rizan Ahmed, Ph.D. | Res Fellow | Immunopathology | Abdel Rahim A Hamad, DVM, Ph.D. | Role of X cell-secreted mAb (x-mAb) in the pathogenesis of Type 1 Diabetes (T1D) |
| Tianyu Cao, B.M. | Grad Stud (Trainee) | Neuropathology | Philip C-Y Wong, Ph.D. | Validation of TDP-43 splicing repression as a therapeutic strategy for ALS- Frontotemporal Dementia |
| Zahra Omidian, DVM, Ph.D. | Res Fellow | Immunopathology | Abdel Rahim A Hamad, DVM, Ph.D. | An unexpected role for x-mAb in inducing anti-insulin antibodies; provides new insights into T1D mechanism |
| J. David Peske, M.D., Ph.D. | Housestaff | Immunopathology | Nilabh Shastri | Shaping of the peptide-MHC Class I repertoire by human ER aminopeptidases |
| Taejoon Won, Ph.D. | Res Fellow | Immunopathology | Daniela Cihakova, M.D., Ph.D. | Autoimmunity against Cardiac Self-Antigen Drives Immune Checkpoint Inhibitor-Associated Myocarditis Development |
| Megan Wood, B.S. | Grad Stud (Molec Microbio & Immunol) | Immunopathology | Daniela Cihakova, M.D., Ph.D. | PD-L1 on macrophages protects from severe collagen induced arthritis in females |
Excellence in CLINICAL RESEARCH
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| John Lin, B.S. | Res Asst | GI/Liver Pathology | James R. Eshleman, M.D., Ph.D. | Improved microsatellite instability detection in endometrial and prostate cancers using long mononucleotide repeat markers |
| Rajeswari Jayakumar, M.D. | Clin Fellow | Heme Path | Amy S. Duffield, M.D., Ph.D. | Pathologic Findings in Patients with Refractory B-Lymphoblastic Leukemia Treated with Blinatumomab |
Excellence in TRANSLATIONAL RESEARCH
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| David Clark, Ph.D. | Res Fellow | Clinical Chemistry | Hui Zhang, Ph.D. | Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma |
| Jiayu Chen, B.A. | Grad Stud (CMM) | GU Pathology | Angelo DeMarzo, M.D., Ph.D. | An in situ atlas of mitochondrial DNA in mammalian tissues reveals high content in stem/progenitor cells |
| Nicolas Giraldo-Castillo, M.D., Ph.D. | Housestaff | Surgical Pathology | Kathleen Burns, M.D., Ph.D. | Transposable Elements and the Tumor Immune Landscape in Human Cancer |
| Ariel Isser, B.S. | Grad Stud (BME) | Immunopathology | Jonathan P. Schneck, M.D., Ph.D. | A Nanoparticle Platform to Expand Antigen Specific CD4+ T cells for Cancer Immunotherapy |
| Janielle Maynard, Ph.D. | Res Fellow | Kidney/GU Pathology | Karen Sfanos, M.S., Ph.D. | Targeting P2X4 Purinergic Receptors in Aggressive Prostate Cancer |
| Stefano Negri, M.D. | Res Fellow | Surgical Pathology | Aaron James, M.D., Ph.D. | Human perivascular stem cells prevent bone graft resorption in osteoporotic contexts by inhibiting osteoclast formation |
| Khoa Pham, M.D. | Res Fellow | Neuropathology | Eric Raabe, M.D., Ph.D. | Novel prodrug of 6-diazo-5-oxo-l-norleucine suppresses MYC-driven medulloblastoma growth and induces apoptosis |
| Yangying Zhou, M.D. | Med Stud | Clinical Chemistry | Qing Kay Li, M.D., Ph.D. | Mapping Human Cancers using Mass Spectrometry-based Data Independent Acquisition (DIA). A Tissue-based Global Proteomic Analysis |
2019
21st Annual Department of Pathology Young Investigators' Day - March 27, 2019
Top Three Presenters in their Category
- Basic: Ahmed Rizwan, Ph.D. & Bo-Ran Choi, M.S., DVM
- Clinical: Stefani Thomas, Ph.D.
- Translational: Nicolas Giraldo-Castillo, M.D, Ph.D.
*Two Basic Top Presenter Awards given due to tie ratings
Excellence in BASIC RESEARCH
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Rizwan Ahmed, Ph.D. | Research Fellow | Immunopathology | Abdel Rahim A Hamad, DVM, Ph.D. | Analysis of antigen-receptor sequences of a unique lymphocyte reveals a T cell-neoantigen encoded in a public BCR of T1D patients |
| Bo-Ran Choi, M.S., DVM | Graduate Student (Pathobiology) | Neuroscience | Shanthini Sockanathan, Ph.D. | Neuronal GDE2 promotes oligodendrocyte maturation via modulation of neuronal Wnt activity |
| Weiwei Cheng, M.D., Ph.D. | Research Fellow | Neuropathology | Shuying Sun, Ph.D. | CRISPR-Cas9 screens identify DDX3X as a modifier of C9ORF72 GGGGCC repeat-associated non-AUG |
| Janelle Montagne, M.S. | Graduate Student (Pathobiology) | Immunopathology | H. Benjamin Larman, Ph.D. | Ultra-Efficient Short Read Sequencing of Immune Receptor Repertoires |
| Zahra Omidian, DVM, Ph.D. | Research Fellow | Immunopathology | Abdel Rahim A Hamad, DVM, Ph.D. | Breaking the 101 rule of adaptive immunity: Cloning and expression of Immunoglobulin and TCR from the same lymphocyte in type 1 diabetes |
| Tim Nieuwenhuis, B.S. | Graduate Student (Genetics) | Cardiac Pathology | Marc K. Halushka, M.D., Ph.D. | Highly Specific, Highly Expressed Genes Contaminate the GTEx Dataset |
| Mohanraj Sadasivam, Ph.D. | Research Fellow | Immunopathology | Abdel Rahim A Hamad, DVM, Ph.D. | Activation and Proliferation of PD-1+ Kidney Double-Negative T Cells Is Dependent on Nonclassical MHC Proteins and IL-2 |
| Srona Sengupta, B.S. | Graduate Student (Immuno) | Immunopathology | Scheherazade Sadegh-Nasseri, Ph.D. | Characterizing the MHC-II immunopeptidome of HIV using a cell-free antigen processing system and peptide:MHC-specific antibodies |
Excellence in CLINICAL RESEARCH
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Stefani Thomas, Ph.D. | Clinical Fellow | Clinical Chemistry | William Clarke, Ph.D. | Harmonization of a targeted mass spectrometry assay to measure thiopurine metabolites for the optimization of leukemia therapy |
| J. David Peske, M.D., Ph.D. | Housestaff | Surgical Pathology | Elizabeth Thompson, M.D., Ph.D. | Adenosquamous Carcinoma of the Pancreas Shows an Active Tumor Immune Microenvironment with Expression of Multiple Immunosuppressive and Immunoregulatory Molecules |
| Maria Adelita Vizcaino Villalobos, M.D. | Research Fellow | Neuropathology | Fausto J. Rodriguez, M.D. | Clinicopathologic Features and Assessment of ADAM3A Gene Copy Gain by FISH in Conjunctival Squamous Cell Carcinoma and its Precursor Lesions (Carcinoma in Situ/Conjunctival Intraepithelial Neoplasia) |
| Derek Allison, M.D. | Clinical Fellow | Cytopathology | Lisa M. Rooper, M.D. | Standalone p16 Immunohistochemistry is a Suboptimal Surrogate for HPV Status in Cervical Lymph Nodes: A Prospective Clinical Experience |
Excellence in TRANSLATIONAL RESEARCH
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Nicolas Giraldo-Castillo, M.D., Ph.D. | Housestaff | Surgical Pathology | Janis M. Taube, M.D., M.S. | Defining the Impact of PD-1/PD-L1 Axis Expression in Melanoma Using Multiplex Immunofluorescence Paired with a Flow Cytometry workflow |
| Tricia Cottrell, M.D., Ph.D. | Housestaff | Surgical Pathology | Janis M. Taube, M.D., M.S. | Pathologic Features of Response to Neoadjuvant Anti-PD-1 in Resected Non-Small Cell Lung Carcinoma (NSCLC): A Proposal for Quantitative Immune-Related Pathologic Response Criteria (irPRC) |
| Emily Maggioncalda, B.S. | Grad Student (Pathobio) | Medicine, Infectious Diseases | Gyanu Lamichhane, Ph.D. | Progressive Mycobacterium Abscessus Lung Infection in C3HeB/FeJ Mice Associated with Corticosteroid Administration |
| Antje Arnold, Ph.D. | Research Fellow | Neuropathology | Eric Raabe, M.D., Ph.D. | Inhibition of the mTOR and MAPK Pathways Suppresses Growth, Induces Apoptosis, and Decreases Vascularity in Pediatric Low Grade Glioma |
| Eva Shrestha, B.A. | Grad Student (Pathobio) | Kidney/GU Pathology | Karen S. Sfanos, Ph.D. | Presence and Consequence of Bacteria in Infected Radical Prostatectomy Tissues and In Vitro Modeling |
| Regina Kwon, M.D., Ph.D. | Housestaff | Kidney/GU Pathology | Andres Matoso, M.D. | Characterization of adult unclassified renal cell carcinoma |
2018
20th Annual Department of Pathology Young Investigators' Day - March 14, 2018
Top Three Presenters in their Category
- Basic: Daniel Ardeljan, B.S.
- Clinical: Danielle Hutchings, M.D.
- Translational: Brad Poore, Ph.D.
Excellence in BASIC RESEARCH
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Daniel Ardeljan, B.S | Med Stud/Grad Stud (Human Genetics) | Heme Path | Kathy Burns, M.D., Ph.D. | The cost of retrotransposition: identifying synthetic lethal interactions in LINE-expressing cells |
| Jacqueline Brosnan-Cashman, Ph.D. | Res Fellow | GU Path | Alan Meeker, Ph.D. | ATRX loss induces hallmarks associated with alternative lengthening of telomeres (ALT) in human glioma cell lines in a cell line-specific manner |
| Mindy Graham, Ph.D. | Res Fellow | GU Path | Christopher Heaphy, Ph.D. | Functional knockout of ATRX or DAXX permits the Alternative Lengthening of Telomeres (ALT) mechanism in prostate cancer cells |
| Xuezhou (Snow) Hou, B.S. | Grad Student (MMI) | Immuno | Daniela Cihakova, M.D., Ph.D. | The intricacies of cardiac networks: cardiac fibroblasts facilitate changes in monocytes to determine heart failure outcomes |
| Janelle M. Montagne, M.S. | Grad Student (Pathobio) | Immuno | Ben Larman, Ph.D. | A Novel Approach to T cell Receptor Repertoire Sequencing |
| Mohanraj Sadasivam, Ph.D. | Res Fellow | Immuno | Abdel Hamad, D.V.M., Ph.D. | Conventional T cells drive local proliferation of non-classical kidney DN T cells by provision of IL-2 |
| Srona Sengupta, B.S. | Grad Student (Immuno) | Immuno | Scheherazade Sadegh-Nasseri, Ph.D. | Assessing non-classical antigen presentation in HIV-infected CD4+ T cells |
| Robin Welsh, M.Sc. | Grad Student (Immuno) | Immuno | Scheherazade Sadegh-Nasseri, Ph.D. | Investigating a role for the MHC class II accessory molecule HLA-DO in autoimmune disease |
| Byung Woo Kim, B.S. | Grad Student (Pathobio) | Neuropath | Lee Martin, Ph.D. | Human Superoxide Dismutase 1 (SOD1) is a Nuclear Protein With Chromatin-Binding Properties: A Possible Novel Mechanism in ALS Pathogenesis |
| Nikolas Ziogas, M.D. | Res Fellow | Neuropath | Vassilis Koliatsos, M.D. | Characterization of the cellular and molecular mechanisms of primary traumatic axonal injury in the mouse with high-resolution anatomical methods |
Excellence in CLINICAL RESEARCH
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Danielle Hutchings, M.D. | Housestaff | GI Path | Ralph Hruban, M.D. | Cancerization of the pancreatic ducts: Demonstration of a common and under-recognized process using immunolabeling of paired duct lesions and invasive pancreatic ductal adenocarcinoma for p53 and Smad4 |
| M. Herman Chui, M.D. | Res Fellow | GYN Path | Russell Vang, M.D. | Clinicopathologic and molecular features of metachronous ovarian serous borderline tumors and subsequent serous carcinomas |
Excellence in TRANSLATIONAL RESEARCH
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Bradley A. Poore, Ph.D. | Grad Student (Pathobio) | Pediatric Oncology | Eric Raabe, M.D., Ph.D. | Metabolic profiling in pediatric low grade glioma identifies glutathione depletion after mTORC1 inhibition and validates everolimus and carboplatin as a potential combination therapy |
| Allison R. Hanaford, Ph.D. | Res Fellow | Pediatric Oncology | Eric H. Raabe, M.D, Ph.D. | In vivo metabolomics reveals a potentially potent combination therapy for MYC-driven medulloblastoma |
| John Hickey, Ph.D. | Grad Student (Bio Eng) | Immuno | Jonathan Schneck, M.D., Ph.D. | High Throughput Enrichment and Identification of Rare Antigen-specific CD8+ T cells |
| Stefani Thomas, Ph.D. | Clin Fellow | Clin Chem | Hui Zhang, Ph.D. | Conservation of clinically-relevant biological signatures of high-grade serous ovarian cancer across proteomic platforms |
2017
19th Annual Department of Pathology Young Investigators' Day -March 23, 2017
Top Three Presenters in their Category
- Basic: Yuseke Kageyama, M.S. and Jonathan Ling, B.S.
- Clinical: Kevan Salimian, M.D., Ph.D.
- Translational: Youngran Park, B.S.
*Two Basic Top Presenter Awards given due to tie ratings
Excellence in BASIC RESEARCH
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Yusuke Kageyama, M.S. | Clinical Staff | Neuropathology | Juan Troncoso | Study of Amyloid Beta: Before Plaque and Tangle |
| Jonathan Ling, Ph.D. | Graduate Student (Pathobiology) | Neuropathology | Philip C. Wong | Cryptic Exons are Repressed by a Family of Repeat-Binding Splicing Factors |
| Daniel Ardeljan, B.S. | Graduate Student (Human Genetics) | Hematologic Pathology | Kathleen H. Burns | Expression of LINE-1 Interspersed Repeats Causes Cytotoxicity |
| Xuzhou (Snow) Hou, B.S. | Graduate Student (Molecular Micro and Immunology) | Immunopathology | Daniela Cihakova | In Vitro Fate Mapping Reveals Monocyte and Macrophage Subsets' Role in the Pathogenesis of Dilated Cardiomyopathy Development |
| Nicola Diny, Ph.D. | Graduate Student (Molecular Micro and Immunology) | Immunopathology | Daniela Cihakova | Eosinophil-Derived IL-4 Drives Progression of Myocarditis to Dilated Cardiomyopathy |
| Yingwei Hu, Ph.D. | Research Fellow | Clinical Chemistry | Hui Zhang | GPQuest: A Software Tool for Automated Analysis of Mass Spectra of Intact-Glycopeptides |
| Aneesh Donde, B.S. | Graduat Student (Neuroscience) | Neuropathology | Philip C. Wong | Splicing Repression is a Major Role of TDP-43 in Motor Neurons |
| Rizwan Ahmed, Ph.D. | Research Fellow | Immunopathology | Abdel R. Hamad | Discovery of an Autoreactive Lymphocyte that Bear an Invariant BCR and αβ TCR in T1D Patients |
Excellence in CLINICAL RESEARCH
| Presenter | Title | Division | Senior Autor | Poster Title |
|---|---|---|---|---|
| Kevan Salimian, M.D., Ph.D. | Housestaff | Cytopathology | Elizabeth Montgomery | Definition of Barrett Esophagus in the United States (US): Support for Retention of a Requirement for Goblet Cells |
| Mariya Sivay, Ph.D. | Research Fellow | Transfusion Medicine | Susan H. Eshleman | Characterization of HIV Seroconverters in a TDF/FTC PrEP Study: HPTN 067/ADAPT |
| Maria Adelita Vizcaino, M.D. | Research Fellow | Neuropathology/ Ophthalmic Pathology | Fausto Rodriguez | Clinicopathologic Study of Granular Cell Astrocytomas |
| Marissa White, M.D. | Housestaff | Surgical Pathology | Ashley Cimino-Mathews | GATA-3 is Negative in Endosalpingiosis: A Useful Marker in Distinguishing Metastatic Breast Carcinoma from a Benign Mimicker |
| Yunjie Li, M.D. | Housestaff | Surgical Pathology | Peter Argani | Re-Evaluation of 32 "Unclassified" Eosinophilic Renal Cell Carcinomas in Young Patients |
Excellence in TRANSLATIONAL RESEARCH
| Presenter | Title | Division | Senior Autor | Poster Title |
|---|---|---|---|---|
| Youngran Park, B.S. | Graduate Student (Pathobiology) | GYN Pathology | Ie-Ming Shih and Tian-Li Wang | Precision Medicine by Applying Radiation Therapy and PARP Inhibitor in ARID1A Mutated Neoplasms |
| Ventzi Hristova, Ph.D. | Clinical Fellow | Clinical Chemistry | Hui Zhang and Daniel Chan | Biomarker Discovery by Proteomic Analysis of Ubiquitin Modification in Ovarian Cancer Cells |
| Yohan Suryo Ramanto, Ph.D. | Research Fellow | GYN Pathology | Tian-Li Wang | ARID1A Regulates Chromatin Structures and Transcription Networks, Causing the Invastion Phenotype of Gynecological Malignancies |
| Michael Haffner, M.D., Ph.D. | Housestaff | Kidney/GU Pathology | Angelo M. DeMarzo | Absent in Melanoma 1 (AIM1) Suppresses Actin Cytoskeletal Remodeling, Cell Migration, and Micrometastatic Dissemination |
| David Clark, Ph.D. | Research Fellow | Clinical Chemistry | Hui Zhang | Comprehensive Analysis of Protein Glycosylation from Prostate Cancer Cells Using Automated Methods to Release Glycans and Glycosite-Containing Peptides |
2016
18th Annual Department of Pathology Young Investigators' Day - March 30, 2016
Top Three Presenters in their Category
- Basic: Nelson Song, B.S. and Jonathan Ling, B.S.
- Clinical: Lisa Rooper, M.D.
- Translational: Michael Haffner, M.D., Ph.D.
*Two Basic Top Presenter Awards given due to tie ratings
Excellence in BASIC RESEARCH
| Presenter | Title | Division | Senior Author | Poster Title |
|---|---|---|---|---|
| Nianbin (Nelson) Song, B.S. | Graduate Student (MMI) | Immunology | Scheherazade Sadegh-Nasseri | MHC class II antigen-processing chaperone H2-O shapes CD4 T cell receptor repertoire |
| Jonathan Ling, B.S. | Graduate Student (Pathobiology) | Neuropathology | Phil Wong, Ph.D. | PTBP1 and PTBP2 are cryptic exon repressors |
| Mindy Kim Graham, Ph.D. | Research Fellow | GU Pathology | Alan Meeker and Christopher Heaphy | Generating and characterizing novel prostate cancer cell lines that employ the Alternative Lengthening of Telomeres (ALT) telomere maintenance |
| Tatsuo Hata, M.D. | Research Fellow | GI/Liver Pathology | Michael Goggins | Cyst fluid telomerase activity predicts the histologic grade of cystic neoplasms of the pancreas |
| Rosie Jiang, B.S. | Graduate Student (Pathobiology) | GYN Pathology | Richard Roden | Spontaneous and vaccine-induced clearance of Mus Musculus Papillomavirus1 (MusPV1) infection |
| Byunghak Kang, D.V.M. | Graduate Student (Pathobiology) | Oncology | Stephen Baylin | Oncogenic BRAFV600E drives stem cell niche factors independent growth and tumorigenic transformation in colon organoids |
| Chih-Ping Mao, B.S. | Graduate Student (MMI) | GYN Pathology | TC Wu | Release of self-DNA underlies the adjuvant effect of chemotherapy and facilitates synergy between antigen-specific vaccination and immune checkpoint blockade |
| Yoshihisa Matsushita, Ph.D. | Research Fellow | GI/Liver Pathology | James Eshleman | Improved differentiation and chemoresponses of pancreatic adenocarcinoma in hanging drop culture |
| Youngran Park, B.S. | Graduate Student (Pathobiology) | GYN Pathology | Ie-Ming Shih and Tian-Li Wang | The caretaker role of ARID1A, a chromatin remodeling protein, in DNA repair and cancer development |
| Corey M. Porter, B.S. | Graduate Student (Pathobiology) | Kidney/GU Pathology | Karen Sfanos | The Induction and Silencing of Lactoferrin, a Putative Prostate Cancer Tumor Suppressor Gene, in the Early Stages of Prostate Neoplasia and Progression |
| Bo-Yi Sung, M.D. | Graduate Student (Pathobiology) | Immunopathology | Jonathan Schneck | Wnt Signaling Induces Polyfunctional Human CD8+ T Cells Associated with PRMTs Expression |
| Robin A. Welsh, M.S. | Graduate Student (MMI) | Immunopathology | Scheherazade Sadegh-Nasseri | Exploring a possible role for the MHC Class II accessory molecule H2-O in the development of experimental autoimmune encephalomyelitis |
Excellence in CLINICAL RESEARCH
| Presenter | Title | Division | Senior Autor | Poster Title |
|---|---|---|---|---|
| Lisa Rooper, M.D. | Housestaff | Surgical Pathology | Ashley Cimino-Mathews | Identifying Targets for Reducing Immunohistochemical Utilization: an Audit of 18,760 Cases |
| Allison B. Chambliss, M.D. | Clinical Fellow | Clinical Chemistry | Mark Marzinke | Rapid Screening for Targeted Genetic Variants via High-Resolution Melting Curve Analysis |
| Genevieve M. Crane, M.D., Ph.D. | Clinical Fellow | Hematologic Pathology | Amy Duffield | Macrophages in Post-Transplant, Relapsed Classical Hodgkin Lymphoma are Donor-Derived |
| Thomas J. Gniadek, M.D., Ph.D. | Housestaff | Transfusion Medicine | Karen King | Passenger Lymphocyte Syndrome Due to Anti-D: Diagnosis, Clinical Course and Quantitative Analysis of Hemolysis |
| Armen Khararjian, M.D., M.B.A. | Housestaff | Surgical Pathology | Alex Baras | The utility of intraoperative gross examination of colorectal resections: a retrospective review of 200 sequential cases |
| Emily R. Nelson, M.D. | Housestaff | Surgical Pathology | Ashley Cimino-Mathews | Reactive Squamous Metaplasia in the Breast: A 20-Year Review with Emphasis on Features Distinguishing Benign Metaplasia from Malignant Lesions |
| Elizabeth Thompson, M.D., Ph.D. | Housestaff | Surgical Pathology | Ashley Cimino-Mathews | PD-L1 Expression and the Immune Microenvironment in Primary Invasive Lobular Carcinomas of the Breast |
| Kevin M. Waters, M.D., Ph.D. | Housestaff | Cardiac/Autopsy Pathology | Marc Halushka | Implementation of the New AECVP/SCVP Aorta Consensus Grading Scheme |
Excellence in TRANSLATIONAL RESEARCH
| Presenter | Title | Division | Senior Autor | Poster Title |
|---|---|---|---|---|
| Michael C. Haffner, M.D., Ph.D. | Housestaff | Kidney/GU Pathology | Angelo DeMarzo | Molecular evidence that invasive adenocarcinoma can mimic prostatic intraepithelial neoplasia (PIN) and intraductal carcinoma through retrograde glandular |
| Javier A. Baena-Del Valle, M.D. | Research Fellow | Kidney/GU Pathology | Angelo DeMarzo | Human telomerase RNA component (hTR/TERC) is consistently overexpressed in prostate cancer, required for cell proliferation and is positively regulated by MYC (c-Myc) |
| Jacqueline A. Brosnan-Cashman, Ph.D. | Research Fellow | GU Pathology | Alan Meeker | ALT-positive pediatric high grade glioma cells display chemosensitivity to ATR pathway inhibition |
| Marija Debeljak, B.S. | Laboratory Tech (functions as student) | GI/Liver Pathology | James Eshleman | Observed Haplotypes in Three Populations for Five Loci |
| Nicola Diny, M.S. | Graduate Student (MMI) | Immunopathology | Daniela Cihakova | The eotaxin-CCR3 pathway recruits eosinophils to the heart during eosinophilic myocarditis |
| Allison R. Hanaford, B.S. | Graduate Student (Pathobiology) | Neuropathology | Charles Eberhart | DiSCoVERing innovative therapies for rare tumors: Combining genetically accurate disease models with advanced in silico analysis to identify novel therapeutic targets |
| Heidi A. Hempel, B.S. | Graduate Student (Pathobiology) | Kidney/GU Pathology | Karen Sfanos | Low Intratumoral Mast Cell Number and Density are Associated with a Higher Risk of Prostate Cancer Recurrence |
| Harpreet Kaur, Ph.D. | Research Fellow | Neuropathology | Charles Eberhart | The transcriptional modulator HMGA2 promotes glioblastoma tumorigenicity and increases sensitivity to ATR inhibitors |
| Brad A. Poore, B.S. | Graduate Student (Pathobiology) | GI/Liver Pathology | Anne Le | Nanotechnology-enhanced delivery of a glutaminase inhibitor: new treatment for pancreatic cancer |
| Samantha L. Semenkow, B.Sc. | Graduate Student (Pathobiology) | Neuropathology | Charles Eberhart | Immune co-stimulatory blockade permits human glioblastoma xenografting in immunocompetent mice: model validation with MRI and bioluminescence imaging |
| Shisheng Sun, Ph.D. | Research Fellow | Clinical Chemistry | Hui Zhang | Comprehensive analysis of protein glycosylation using N-linked glycans and glycosite-containing (NGAG) method |