Professor, Department of Pathology, Oncology and Urology, Johns Hopkins University
AP Resident: 1994-1997
Chief Resident: 1996-1997
Dr. De Marzo is a Professor of Pathology, Oncology and Urology at The Johns Hopkins University School of Medicine. He is a member of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, where he serves as Associate Director for Pathology Cancer Research.
He came to Johns Hopkins in 1994 for a residency in anatomic pathology after completing the M.S.T.P. at the University of Colorado. During his AP training he placed special emphasis on genitourinary pathology under the guidance of Jonathan Epstein, M.D. and then completed a research fellowship with Donald S. Coffey, Ph.D., in 1998.
Dr. De Marzo directs a basic/translational research lab in which the group studies molecular mechanisms involved in prostate cancer initiation and progression with particular emphasis on the roles MYC, and PTEN, as well as, the role of inflammation in prostate cancer. This work involves the extensive use of human prostatectomy specimens and cell lines as well as collaborative work on the development and characterization of novel genetically engineered animal models of prostate cancer, and inflammation. The group also works closely with members of the Bloomberg School of Public Health to perform "Patho-Epidemiology" studies.
His translational research efforts focus on analytically validating and interrogating biomarker expression in human tissues, where such biomarkers may be used for diagnostic, prognostic, predictive and pharmacodynamic monitoring.
Dr. De Marzo is Board Certified in anatomic pathology and his sign-out focuses nearly exclusively on prostate cancer. He also directs the NIH/NCI Prostate SPORE Pathology Core/Biospecimen Bank, and is co-director of the Prostate Cancer Biospecimen Network (PCBN) which is a DOD funded biorepository. Dr. De Marzo has mentored a number of postdoctoral fellows (pathologists, urologists and PhD scientists) who have moved on to academic faculty positions and also serves as a faculty advisor to Pathobiology graduate students and is active in teaching in the Pathobiology Graduate Program.