Chairman, Department of Pathology, Northwestern University
AP Resident: 1994-1997
Neuropathology Fellow: 1997-1999
Dr. Brat received his M.D., Ph.D. from the Mayo Medical and Graduate Schools. He then completed a residency in Anatomic Pathology and a fellowship in Neuropathology at Johns Hopkins Hospital. He joined the Department of Pathology and Laboratory Medicine at Emory University in 1999 and is now Chairman of Pathology at Northwestern University in Chicago.
He directs a basic and translational research lab that investigates mechanisms of glioma progression, including the contributions of hypoxia, genetics, tumor microenvironment and stem cells. His laboratory has been continuously funded by the NIH and the Georgia Research Alliance as a Distinguished Cancer Scholar.
He also leads the scientific efforts of the In Silico Center for Brain Tumor Research at Emory, which uses large scale clinical and molecular databases, such as The Cancer Genome Atlas (TCGA), to address fundamental questions in human glioma behavior. He has over 16 years of experience in brain tumor research and has written more than 200 peer-reviewed manuscripts and reviews.
He has also co-authored two textbooks in Neuropathology: Practical Surgical Neuropathology: A Diagnostic Approach and Biopsy Interpretation of Central Nervous System. Dr. Brat is the Director of the Cancer Tissue and Pathology Shared Resource at Winship, which includes a full service histology laboratory and a tissue procurement service. He is Board certified in Anatomic and Neuropathology and understands the critical issues in current neuro-oncology practice and research. He sits on five Editorial Boards and has served on numerous committees that oversee translational investigation in Oncology and Pathology, including the TCGA Glioblastoma and Lower Grade Gliomas (Co-Chair) Working Groups; the College of American Pathologists (CAP) Neuropathology Committee (Chair) and Council on Scientific Affairs; the Executive Council of the American Association of Neuropathologists; the Board of Directors for the Society of Neuro-oncology; and the WHO Committee for Classification of Brain Tumors. He is a member of the American Society for Clinical Investigation.