Neuropathology Fellowship

This ACGME-accredited fellowship program in experimental neuropathology is designed to teach new MD, MD/PhD, and PhD investigators basic science approaches to disorders of the nervous system.

Major research efforts focus on the neurobiology/neuropathology and pathogenic mechanisms involved in a variety of illnesses, particularly the neurodegenerative diseases, including amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, and Parkinson's disease. In parallel, our group has examined in vitro and in vivo experimental systems with particular emphasis on animal models of neurodegenerative diseases. More recently, we have used gene targeting and transgenic approaches to define the function of specific gene products and to examine the consequences of introduction of disease-linked mutations into transgenic mice. These transgenic models are of great value for investigations of disease mechanisms and will be critical for testing novel therapies that, if efficacious in model systems, can be rapidly introduced into clinical trials.

Other areas of high research priority are: neurotrophic factors and their influence on injured neurons; the biology of brain tumors with an emphasis on the roles of specific genes in neoplasm; and the mechanisms of cell injury in hypoxia-ischemia. Under individual faculty supervision, trainees work on several projects and become familiar with techniques of molecular neurobiology, biochemistry, ultrastructure, immunocytochemistry, receptor autoradiography, etc. A separate residency training program, leading to eligibility for Board certification in Neuropathology, is also available to individuals with prior training in Pathology or Neuropathology.

Send the application (via email) to:

Juan C. Troncoso, M.D., Program Director
The Johns Hopkins Hospital
Department of Pathology, Ross 558
720 Rutland Avenue
Baltimore, Maryland 21287

Phone: 410-955-5632
Fax: 410-955-9777
Email: [email protected]